Cytologic changes in small hepatocellular carcinomas after radiofrequency ablation.

作者信息

Lin Shi-Ming, Shen Chien-Heng, Lin Deng-Yn, Kuo Sow-Hsong, Lin Chun-Jung, Hsu Chao-Wei, Chung Hock-Jean, Peng Cheng-Yuan

机构信息

Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan.

出版信息

Acta Cytol. 2002 May-Jun;46(3):490-4. doi: 10.1159/000326866.

DOI:10.1159/000326866

PMID:12040642

Abstract

OBJECTIVE

To illustrate the cytologic changes in hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA).

STUDY DESIGN

The study included 20 patients with 23 HCC who had undergone RFA under ultrasound guidance. Baseline cytomorphology of HCC was evaluated by fine needle aspiration (FNA) in all cases. Triphasic helical computed tomography (CT) and FNA cytology were done to evaluate the efficacy of the treatment within two weeks after RFA. The cytologic specimens were stained with Riu's method (Romanowsky stain).

RESULTS

A range of cytologic findings after RFA was found, including granular and amorphous debris with artefactual aggregation, degenerated cells or necrotic material, and dyshesive, degenerated cells in a necrotic background. The cytologic patterns included necrotic cells and debris in 14 tumors and fine, granular necrosis in 9. Helical CT showed no enhancement in any of the tumors after RFA.