Turek P, Dudek D, Zmudka K, Dubiel J S
II Klinika Kardiologii Collegium Medicum, Uniwersytetu Jagiellońskiego, Kraków.
Przegl Lek. 2001;58(12):1071-5.
The most frequent cause of secondary arterial hypertension is renal artery stenosis. The aetiology of renal artery stenosis is mainly atherosclerotic (75-80%), in the remaining cases fibromuscular dysplasia is the causative factor. Renovascular hypertension has a poorer prognosis than spontaneous because it is more resistant to antihypertensive treatment, signifies an increased risk for the development and progression of malignant hypertension and may lead to irreversible renal dysfunction due to ischaemia. Renal revascularisation has been proved an effective treatment modality in patients with arterial hypertension or renal failure due to renal artery stenosis. However, surgical treatment is associated with the mortality rate of 6-9% due to the concomitant presence of ischaemic heart disease, cerebral and peripheral arteriosclerosis. Percutaneous transluminal renal angioplasty is equally effective in the treatment of arterial hypertension as surgical operation, leading to the improvement or stabilisation of renal function. The advent of renal stenting has markedly changed the efficacy and safety of procedures with PTRA becoming an alternative to surgery. The high efficacy of PTRA is associated with low mortality and relatively few complications as compared with surgical treatment. However, there is continuous discussion concerning the efficacy of percutaneous and surgical renal revascularisation in arterial hypertension. PTRA is currently increasingly frequently recommended in patients with renovascular hypertension not only to control blood pressure but also to protect renal function.
继发性动脉高血压最常见的病因是肾动脉狭窄。肾动脉狭窄的病因主要是动脉粥样硬化(75 - 80%),其余病例中纤维肌性发育异常是致病因素。肾血管性高血压的预后比原发性高血压差,因为它对抗高血压治疗更具抵抗性,意味着恶性高血压发生和进展的风险增加,并且可能由于缺血导致不可逆的肾功能障碍。肾血管重建术已被证明是治疗因肾动脉狭窄导致的动脉高血压或肾衰竭患者的有效治疗方式。然而,由于同时存在缺血性心脏病、脑和外周动脉硬化,手术治疗的死亡率为6 - 9%。经皮腔内肾血管成形术在治疗动脉高血压方面与手术同样有效,可使肾功能得到改善或稳定。肾支架置入术的出现显著改变了治疗效果和安全性,使经皮腔内肾血管成形术成为手术的替代方法。与手术治疗相比,经皮腔内肾血管成形术的高效性与低死亡率和相对较少的并发症相关。然而,关于经皮和手术肾血管重建术在动脉高血压治疗中的疗效仍存在持续的讨论。目前,经皮腔内肾血管成形术在肾血管性高血压患者中越来越频繁地被推荐,不仅用于控制血压,还用于保护肾功能。