Defining and quantifying the social phenotype in autism.

OBJECTIVE

Genetic and neurofunctional research in autism has highlighted the need for improved characterization of the core social disorder defining the broad spectrum of syndrome manifestations.

METHOD

This article reviews the advantages and limitations of current methods for the refinement and quantification of this highly heterogeneous social phenotype.

RESULTS

The study of social visual pursuit by use of eye-tracking technology is offered as a paradigm for novel tools incorporating these requirements and as a research effort that builds on the emerging synergy of different branches of social neuroscience.

CONCLUSIONS

Advances in the area will require increased consideration of processes underlying experimental results and a closer approximation of experimental methods to the naturalistic demands inherent in real-life social situations.