El-Toukhy Tarek, Khalaf Yacoub, Hart Roger, Taylor Alison, Braude Peter
Assisted Conception Unit, 4th Floor, Thomas Guy House, Guy's and St Thomas' Hospital NHS Trust, St Thomas' Street, London SE1 9RT, UK.
Hum Reprod. 2002 Jun;17(6):1519-24. doi: 10.1093/humrep/17.6.1519.
Ovarian reserve significantly influences IVF outcome. Low response to ovarian stimulation due to reduction of ovarian reserve is occasionally encountered in young women. The aim of this study was to evaluate the outcome of IVF treatment in young patients with reduced ovarian reserve.
Between January 1993-2001, 762 consecutive patients satisfied the definition of reduced ovarian reserve (raised early follicular phase FSH or gonadotrophin stimulation cycles where three or fewer oocytes were retrieved after routine FSH stimulation) and were included in the study. They were classified into three age groups: young (< or = 30 years), intermediate (31-38 years) and older (>38 years). The three age groups were similar with respect to basal (day 3) serum FSH and estradiol concentrations, cause of infertility and number of previous treatment cycles. Implantation (13, 9.6 and 9.8%), clinical pregnancy (11.8, 10.2 and 10%) and live birth (7.4, 7.3 and 6.8%) rates were not significantly different in the three age groups respectively (P > 0.05).
This study shows that younger patients with reduced ovarian reserve have a poor outcome of IVF treatment similar to their older counterparts. Such information may be helpful in counselling these patients who otherwise might anticipate an outcome related to their chronological age.
卵巢储备显著影响体外受精（IVF）的结局。年轻女性偶尔会出现因卵巢储备减少而对卵巢刺激反应低下的情况。本研究的目的是评估卵巢储备减少的年轻患者的IVF治疗结局。
在1993年1月至2001年期间，762例连续患者符合卵巢储备减少的定义（卵泡早期促卵泡激素升高或在常规促卵泡激素刺激后获得三个或更少卵母细胞的促性腺激素刺激周期）并纳入本研究。她们被分为三个年龄组：年轻组（≤30岁）、中年组（31 - 38岁）和老年组（>38岁）。三个年龄组在基础（第3天）血清促卵泡激素和雌二醇浓度、不孕原因以及既往治疗周期数方面相似。三个年龄组的着床率（分别为13%、9.6%和9.8%）、临床妊娠率（分别为11.8%、10.2%和10%）和活产率（分别为7.4%、7.3%和6.8%）差异均无统计学意义（P>0.05）。
本研究表明，卵巢储备减少的年轻患者IVF治疗结局与老年患者相似，较差。此类信息可能有助于为这些患者提供咨询，否则他们可能会预期与实际年龄相关的结局。
