DNA拓扑异构酶的细胞作用：分子视角

Cellular roles of DNA topoisomerases: a molecular perspective.

作者信息

Wang James C

机构信息

Department of Molecular and Cellular Biology, Harvard University, Fairchild Building, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA.

出版信息

Nat Rev Mol Cell Biol. 2002 Jun;3(6):430-40. doi: 10.1038/nrm831.

DOI:10.1038/nrm831

PMID:12042765

Abstract

DNA topoisomerases are the magicians of the DNA world by allowing DNA strands or double helices to pass through each other, they can solve all of the topological problems of DNA in replication, transcription and other cellular transactions. Extensive biochemical and structural studies over the past three decades have provided molecular models of how the various subfamilies of DNA topoisomerase manipulate DNA. In this review, the cellular roles of these enzymes are examined from a molecular point of view.

摘要

DNA拓扑异构酶堪称DNA世界的魔术师，它们能让DNA链或双螺旋相互穿过，从而解决DNA在复制、转录及其他细胞活动中出现的所有拓扑学问题。在过去三十年里，广泛的生化和结构研究为DNA拓扑异构酶各亚家族如何操控DNA提供了分子模型。在这篇综述中，我们将从分子角度审视这些酶在细胞中的作用。