Okada Y
J Oral Pathol. 1979 Dec;8(6):340-50. doi: 10.1111/j.1600-0714.1979.tb01837.x.
Histopathological studies were conducted on experimental carcinogenesis in mouse salivary glands using D L-isoproterenol hydochloride (isoproterenol) and 9 10-dimethyl-1 2-benzanthracene (DMBA). DMBA was administered once at 1 mg/0.02 ml in olive oil to the salivary glands, and isoproterenol was injected intraperitoneally at 1 mg/0.05 ml saline solution three times a week for 2 weeks at different periods during the oncogenic process. Salivary glands treated with carcinogen showed a relatively constant sequence of changes and developed epithelial and mesenchymal tumors irrespective of isoproterenol administration. Isoproterenol did not influence the development of another type of tumor; however, it did retard the oncogenic processes.
利用盐酸 DL - 异丙肾上腺素（异丙肾上腺素）和 9,10 - 二甲基 - 1,2 - 苯并蒽（DMBA）对小鼠唾液腺进行实验性致癌的组织病理学研究。将 DMBA 以 1 mg/0.02 ml 溶于橄榄油中一次性注射到唾液腺，在致癌过程的不同阶段，将异丙肾上腺素以 1 mg/0.05 ml 生理盐水腹腔注射，每周三次，持续 2 周。用致癌物处理的唾液腺显示出相对恒定的变化序列，无论是否给予异丙肾上腺素，都会发生上皮和间充质肿瘤。异丙肾上腺素不影响另一种类型肿瘤的发生；然而，它确实延缓了致癌过程。
