Nguyen Minh, Gregan Angel
Aust Fam Physician. 2002 Apr;31(4):339-43.
Depression is one on the most common psychological problems encountered in medical practice. Conventional antidepressants, although effective, have many side effects and there is a need for effective medications with fewer side effects.
To present all the available clinical evidence on the supplement, S-adenosylmethionine (SAMe) in the treatment of depressive symptoms as well as its safety.
Recent clinical studies have revealed that SAMe, a naturally occurring molecule, is safe and effective in the treatment of mild and moderate depression. Although further research is required to clarify SAMe's role as a potential first line treatment for depression, physicians should be aware of the safety and efficacy of SAMe in order to advise patients on its appropriate use as complementary or as an alternative to traditional therapy for depression.
抑郁症是医疗实践中最常见的心理问题之一。传统抗抑郁药虽然有效，但有许多副作用，因此需要副作用更少的有效药物。
提供关于补充剂S-腺苷甲硫氨酸（SAMe）治疗抑郁症状及其安全性的所有现有临床证据。
最近的临床研究表明，SAMe这种天然存在的分子在治疗轻度和中度抑郁症方面是安全有效的。尽管需要进一步研究以阐明SAMe作为抑郁症潜在一线治疗方法的作用，但医生应了解SAMe的安全性和有效性，以便就其作为抑郁症传统治疗的补充或替代方法的适当使用向患者提供建议。
