Stein P C, Basch P F
J Parasitol. 1979 Dec;65(6):862-9.
Mice and rabbits were immunized with antigens derived from Bge cells, Biomphalaria glabrata hemolymph, or Schistosoma mansoni. Antisera from mice given molluscan antigens did not form immunoprecipitates with soluble antigen from adult worms, but their binding to surfaces of sporocysts, cercariae, and schistosomules suggests the presence of cross-reacting determinants. In vitro, cell-mediated immune responses to Bge antigens were not demonstrable in infected nor in immunized mice. Mice immunized with Bge cell-line antigens and challenged with S. mansoni cercariae showed no reduction in worm burden when compared with control mice.
用源自Bge细胞、光滑双脐螺血淋巴或曼氏血吸虫的抗原对小鼠和兔子进行免疫。给予软体动物抗原的小鼠产生的抗血清不能与成虫的可溶性抗原形成免疫沉淀物，但它们与子孢蚴、尾蚴和童虫表面的结合表明存在交叉反应性决定簇。在体外，无论是感染的小鼠还是免疫的小鼠，对Bge抗原的细胞介导免疫反应均未得到证实。用Bge细胞系抗原免疫并用曼氏血吸虫尾蚴攻击的小鼠，与对照小鼠相比，虫负荷没有降低。
