Ekiel Alicja, Friedek Daniela, Szulakowski Patryk, Romanik Małgorzata, Rogala-Zawada Danuta, Wilk Iwona
Katedry i Zakładu Mikrobiologii oraz, Slaskiej Akademii Medycznej w Katowicach.
Wiad Lek. 2002;55(1-2):11-8.
Chronic bacterial infections intensify the reactivity of bronchi and aggravate the course and the control of asthma. They cause the disorders of both function and the structure of respiratory epithelium. Not only structural elements of bacteria but also their toxins intensify the release of mediators of the inflammatory reaction (leucotriens, histamine, IL1, IL4, IL6, IL8, TNF alpha). The aim of our research is to determine the prevalence of microorganisms, which can have an influence on the course of asthma. Moraxella catarrhalis has been the most frequent isolated pathogen (23.7%) in patients with bronchial asthma. We have received only individual isolations of Streptococcus pneumoniae and Haemophilus influenzae strains. Bacterial flora of the upper respiratory tract in patients with bronchial asthma has been more diverse in comparison with microflora of airways in healthy subjects. The significant percentage of Candida isolation in asthmatics (over 30% in bronchial tree secretion) poses the high risk of incidence of mycotic complications of inhaled steroids. In patients with asthma bronchial tree secretion is more valuable diagnostic material than pharyngeal swab.
慢性细菌感染会增强支气管的反应性，加重哮喘的病程及控制难度。它们会导致呼吸上皮的功能和结构紊乱。不仅细菌的结构成分，其毒素也会增强炎症反应介质（白三烯、组胺、白细胞介素1、白细胞介素4、白细胞介素6、白细胞介素8、肿瘤坏死因子α）的释放。我们研究的目的是确定可能影响哮喘病程的微生物的流行情况。卡他莫拉菌是支气管哮喘患者中最常分离出的病原体（23.7%）。我们仅个别分离出肺炎链球菌和流感嗜血杆菌菌株。与健康受试者气道的微生物群相比，支气管哮喘患者上呼吸道的细菌菌群更为多样。哮喘患者中念珠菌分离的比例较高（支气管树分泌物中超过30%），这增加了吸入性类固醇发生真菌并发症的风险。对于哮喘患者，支气管树分泌物比咽拭子更具诊断价值。
