Karpe Fredrik
Oxford Lipid Metabolism Group, Oxford Centre for Diabetes, Metabolism and Endocrinology, Radcliffe infirmary, UK.
Atheroscler Suppl. 2002 May;3(1):41-6. doi: 10.1016/s1567-5688(01)00004-6.
Exaggerated postprandial hyperlipidemia has been associated with cardiovascular disease. The mechanisms underlying this association are likely to depend on a multitude of effects. Potentially atherogenic remnants of triglyceride-rich lipoproteins (TRL) accumulate in the postprandial state. In addition, TRL may promote the formation of small dense LDL. There are some indications that the postprandial period is a hypercoagulable state and endothelial function seems to be hampered after acute fat intake. Conventional lipid lowering drugs such as statins and fibrates have the potency of reducing postprandial hyperlipidemia, but the fibrates seem to be more effective in this respect. There is a complete lack of prospective studies linking inefficient postprandial lipid metabolism with clinical endpoints and there is also a need to include investigations of postprandial lipid metabolism in the evaluation of novel drugs affecting lipid metabolism and insulin resistance.
餐后高脂血症与心血管疾病有关。这种关联背后的机制可能取决于多种效应。富含甘油三酯的脂蛋白（TRL）潜在的致动脉粥样硬化残余物在餐后状态下会积聚。此外，TRL可能会促进小而密低密度脂蛋白的形成。有一些迹象表明，餐后时期处于高凝状态，急性脂肪摄入后内皮功能似乎会受到损害。传统的降脂药物如他汀类和贝特类药物有降低餐后高脂血症的效力，但贝特类药物在这方面似乎更有效。完全缺乏将餐后脂质代谢效率低下与临床终点联系起来的前瞻性研究，并且在评估影响脂质代谢和胰岛素抵抗的新药时也需要纳入餐后脂质代谢的研究。
