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[类似于羧基异羟肟酸色酮-2(钠盐)的分子在实验性氯化汞中毒中的活性;色酮循环的重要性]

[Activities of molecules similar to carboxyhydroxamic acid chromone-2 (sodium salt) in experimental mercury chloride poisoning; importance of the chromone cycle].

作者信息

Fialip L, Payard M, Bastide P, Ralite P, Teillard Y

出版信息

Eur J Toxicol Environ Hyg. 1975 Nov-Dec;8(6):347-52.

PMID:1204673
Abstract

The carbo-hydroxamic-2 chromone acid (sodium salt) shows a higher protective action in vivo than in vitro against mercury chloride induced intoxications. The higher effect observed in vivo might be due to the activity itself of the chromone cycle which added up to that of the carbo-hydroxamic acid function. This latter alone appears in vitro. The antihyaluronidasic properties of this protective agent allow it to prevent the toxic substances to be diffused.

摘要

碳酰氧肟酸 -2 - 色酮酸(钠盐)在体内对氯化汞诱导的中毒表现出比体外更高的保护作用。在体内观察到的更高效果可能归因于色酮环本身的活性,它与碳酰氧肟酸官能团的活性相加。后者单独在体外出现。这种保护剂的抗透明质酸酶特性使其能够防止有毒物质扩散。

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