Miyamoto Tomoyuki, Miyamoto Masayuki, Suga Takako, Aizawa Chie, Takekawa Hidehiro, Hirata Koichi
Department of Neurology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan.
Psychiatry Clin Neurosci. 2002 Jun;56(3):271-2. doi: 10.1046/j.1440-1819.2002.00965.x.
A 28-year-old man with a history of myotonic dystrophy (MyD) is described. His progressively worsening excessive daytime sleepiness (EDS) was treated with methylphenidate hydrochloride. Polysomonography (PSG), the multiple sleep latency test (MSLT), middle latency-evoked response, and auditory event-related potentials were used to assess the cause of EDS. The PSG detected small numbers of central sleep apneic episodes. Mean sleep latency, which was determined by MSLT, increased from 5 min before treatment to 14 min after treatment. The Pa, P1, and N1 amplitudes at the Cz site increased after treatment, but P3 latency remained unchanged. These observations suggest that EDS and impairment of cognitive and information processing seen in a patient with MyD may be caused by a central nervous system disorder.
本文描述了一名患有强直性肌营养不良（MyD）的28岁男性。他进行性加重的日间过度嗜睡（EDS）采用盐酸哌甲酯治疗。通过多导睡眠图（PSG）、多次睡眠潜伏期试验（MSLT）、中潜伏期诱发电位和听觉事件相关电位来评估EDS的病因。PSG检测到少量中枢性睡眠呼吸暂停发作。由MSLT测定的平均睡眠潜伏期从治疗前的5分钟增加到治疗后的14分钟。治疗后Cz部位的Pa、P1和N1波幅增加，但P3潜伏期保持不变。这些观察结果表明，MyD患者出现的EDS以及认知和信息处理障碍可能由中枢神经系统疾病引起。
