Wang Garrick K, Sehgal Amita
Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, 232 Stemmler Hall, 35th Street & Hamilton Walk, Philadelphia, Pennsylvania 19104, USA.
Curr Opin Neurobiol. 2002 Jun;12(3):331-8. doi: 10.1016/s0959-4388(02)00324-0.
In the past year, knowledge of how information is relayed in the regulation of circadian rhythms has advanced considerably. Experiments using genetic knockout animals suggest that circadian photoreception consists of an integration of multiple signaling pathways. Versatility of clock proteins is seen in terms of their function in the central pacemakers versus the periphery. This versatility also extends to previously identified molecules, such as retinoid receptors, redox factors and mitogen-activated protein kinase, that have newly identified roles in circadian signaling pathways. Advances in circadian research over the past year include the common themes of redundancy and plasticity.
在过去的一年里，关于昼夜节律调节中信息如何传递的知识有了显著进展。使用基因敲除动物的实验表明，昼夜光感受由多种信号通路的整合组成。时钟蛋白的多功能性体现在它们在中央起搏器与外周的功能方面。这种多功能性还扩展到先前已确定的分子，如类视黄醇受体、氧化还原因子和丝裂原活化蛋白激酶，它们在昼夜信号通路中具有新确定的作用。过去一年昼夜节律研究的进展包括冗余和可塑性等共同主题。
