昼夜节律转录：将组蛋白乙酰转移酶传递给生物钟蛋白
Circadian transcription: passing the HAT to CLOCK.
作者信息
Hardin Paul E, Yu Wangjie
机构信息
Department of Biology and Center for Research on Biological Clocks, Texas A&M University, College Station, TX 77843, USA.
出版信息
Cell. 2006 May 5;125(3):424-6. doi: 10.1016/j.cell.2006.04.010.
In animals, the circadian timekeeping mechanism relies on the coordinated activities of activators and repressors to control rhythmic transcription. In this issue of Cell, Doi et al. (2006) reveal that rhythms in histone acetylation are necessary for rhythmic transcription and that the histone acetyl transferase responsible is CLOCK, a key transcription factor that is essential for circadian oscillator function.
在动物中，昼夜节律计时机制依靠激活因子和抑制因子的协同活动来控制节律性转录。在本期《细胞》杂志中，Doi等人（2006年）揭示，组蛋白乙酰化的节律对于节律性转录是必要的，而且负责此过程的组蛋白乙酰转移酶是CLOCK，它是一种对昼夜节律振荡器功能至关重要的关键转录因子。
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