Behrend Ellen N, Kemppainen Robert J, Clark Terrence P, Salman M D, Peterson Mark E
Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, AL 36849, USA.
J Am Vet Med Assoc. 2002 Jun 1;220(11):1643-9. doi: 10.2460/javma.2002.220.1643.
To determine testing protocols used by board-certified internists and dermatologists for diagnosis of hyperadrenocorticism (HAC) in dogs.
Survey.
Board-certified internists and dermatologists.
A questionnaire was mailed to 501 specialists to gather information pertaining to diagnosis of HAC.
206 surveys were returned. Only 26% of respondents indicated they would screen a dog for HAC if the dog had only a few laboratory abnormalities consistent with HAC and no clinical signs consistent with the disease; 31% indicated they would not, and 43% indicated they would sometimes. Overall, 55% of respondents indicated they preferred to use the low-dose dexamethasone suppression test for routine screening of dogs suspected to have HAC. However, many respondents indicated they would use a different screening test than usual in particular circumstances. Sixty-eight percent of respondents indicated they would perform a second screening test for confirmation if results of an initial screening test were positive but there were few clinical or laboratory abnormalities consistent with HAC. Most respondents used some sort of test to differentiate pituitary-dependent HAC from HAC secondary to an adrenal tumor (AT), but no 1 test was clearly preferred. Ultrasonography was commonly used, whereas computed tomography and magnetic resonance imaging were not, even if available.
Results suggest that the low-dose dexamethasone suppression test is the test most commonly used to screen dogs for HAC but that other tests may be used in certain circumstances. A variety of tests were used to differentiate pituitary-dependent HAC from HAC secondary to an AT.
确定获得认证的内科医生和皮肤科医生用于诊断犬肾上腺皮质功能亢进症（HAC）的检测方案。
调查。
获得认证的内科医生和皮肤科医生。
向501名专家邮寄了一份问卷，以收集与HAC诊断相关的信息。
共收回206份调查问卷。只有26%的受访者表示，如果犬只仅有一些与HAC相符的实验室异常，而无该病的临床症状，他们会对其进行HAC筛查；31%的受访者表示不会，43%的受访者表示有时会。总体而言，55%的受访者表示他们更倾向于使用低剂量地塞米松抑制试验对疑似患有HAC的犬只进行常规筛查。然而，许多受访者表示在特定情况下会使用与通常不同的筛查试验。68%的受访者表示，如果初始筛查试验结果为阳性，但与HAC相符的临床或实验室异常较少，他们会进行第二次筛查试验以进行确认。大多数受访者使用某种检测方法来区分垂体依赖性HAC和肾上腺肿瘤（AT）继发的HAC，但没有一种检测方法明显更受青睐。超声检查常用，而计算机断层扫描和磁共振成像即使可用也不常用。
结果表明，低剂量地塞米松抑制试验是最常用于筛查犬HAC的试验，但在某些情况下可能会使用其他试验。多种检测方法用于区分垂体依赖性HAC和AT继发的HAC。
