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癌症化疗与杂环化合物

Cancer chemotherapy and heterocyclic compounds.

作者信息

Kidwai M, Venkataramanan R, Mohan R, Sapra P

机构信息

Department of Chemistry, University of Delhi, India.

出版信息

Curr Med Chem. 2002 Jun;9(12):1209-28. doi: 10.2174/0929867023370059.

Abstract

The search for pharmacological approaches to neoplastic disease has made some impressive gains started after 1940 when the antileukemic activity of nitrogen mustard was discovered during world war II. It is generally accepted that neoplastic transformation is related to genes alteration or oncogene activation, so the progress in the development of the new drugs for treatment of malignant diseases has been rapid, both in revealing pathobiology of the diseases and discovery of new drugs. In addition attempts have been made to define optimal combinations, treatment strategies and patient support measures. Cancer chemotherapy is now of established value and a highly specialized field. Among the modifications to the family of antitumor compounds, heterocyclic organic compounds have been extensively applied by many groups in order to modify the reactivity profile. Pyrrole, pyrimidine, indole, quinoline and purine are few classes of heterocycles which showed interesting cytotoxicity profiles. The updated material related to these modifications has been rationalized and ordered, in order to offer an overview of the argument.

摘要

自1940年二战期间发现氮芥的抗白血病活性后,针对肿瘤疾病的药理学研究方法取得了一些令人瞩目的进展。人们普遍认为肿瘤转化与基因改变或癌基因激活有关,因此在揭示疾病病理生物学和发现新药方面,治疗恶性疾病的新药开发进展迅速。此外,人们还尝试确定最佳组合、治疗策略和患者支持措施。癌症化疗如今已具有既定价值且是一个高度专业化的领域。在抗肿瘤化合物家族的改进中,许多团队广泛应用杂环有机化合物以改变反应活性。吡咯、嘧啶、吲哚、喹啉和嘌呤是几类显示出有趣细胞毒性特征的杂环化合物。与这些改进相关的最新材料已进行了合理化整理和排序,以便对该主题进行概述。

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