包含4,5,6,7-四氢苯并[b]噻吩的新型杂环化合物的合成及其细胞毒性评估。
Synthesis of Novel Heterocyclic Compounds Incorporate 4,5,6,7-Tetrahydrobenzo[b]thiophene Together with Their Cytotoxic Evaluations.
作者信息
Abdallah Amira Elsayed Mahmoud, Mohareb Rafat Milad, Khalil Eid Metwally, Elshamy Menna Alla Mohamed Abd Elaleem
机构信息
Department of Chemistry, Faculty of Science, Helwan University.
Department of Chemistry, Faculty of Science, Cairo University.
出版信息
Chem Pharm Bull (Tokyo). 2017;65(5):469-477. doi: 10.1248/cpb.c16-00925.
The 2-amino-3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophene was the key starting compound used to synthesize new thiazole, pyrimidine, pyran, pyridine and thiazine derivatives. The cytotoxicity of the synthesized compounds was studied towards the three cancer cell lines namely MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) and SF-268 (central nervous system (CNS) cancer) in addition to the normal cell line (WI-38) using doxorubicin as the reference drug. The study showed that compounds 5, 9a, 15b, 17c, 18 and 21b were the most potent compounds.
2-氨基-3-氰基-4,5,6,7-四氢苯并[b]噻吩是用于合成新的噻唑、嘧啶、吡喃、吡啶和噻嗪衍生物的关键起始化合物。除正常细胞系（WI-38）外，还以阿霉素作为参比药物，研究了合成化合物对三种癌细胞系即MCF-7（乳腺腺癌）、NCI-H460（非小细胞肺癌）和SF-268（中枢神经系统（CNS）癌）的细胞毒性。研究表明，化合物5、9a、15b、17c、18和21b是最有效的化合物。
Zotero 插件