Dvorák M, Kocna P, Vanícková Z
IV. interní klinika 1. LF UK a VFN, Praha.
Cas Lek Cesk. 2002 Apr 12;141(7):217-9.
Test of occult fecal blood loss belongs to the basic diagnostic procedures in gastroenterology. That examination is introductory method for screening, diagnosis and dispensarization of patients with colorectal cancer. Most frequently used tests in practice are biochemical and immunochemical tests. The aim of the study was to compare the results and clinical contribution of both kinds of tests.
The results of immunochemical test Immocare (Care Diagnostica) and biochemical test Haemoccult (Röhm Pharma) were compared in a group of 253 patients (131 women, 122 men, average age 52.6 yr, range 19-88 yr). In all patients total coloscopy was subsequently performed. Sensitivity of immunochemical test was clearly higher (61.2%) than of biochemical test (29.4%), specificity was slight lower (95%, resp. 98%). Accuracy of Immocare test was also higher (82% than 72% of Haemoccult).
Our results confirm advantages and competency of Haemoccult test for screening and dispensary programmes. More expensive and more difficult Immocare test is suitable for examination of symptomatic or risk patients.
潜血试验是胃肠病学的基本诊断方法之一。该检查是结直肠癌患者筛查、诊断及分级诊疗的初步方法。实际应用中最常用的检测方法是生化检测和免疫化学检测。本研究旨在比较这两种检测方法的结果及临床价值。
对253例患者（131例女性，122例男性，平均年龄52.6岁，年龄范围19 - 88岁）进行了免疫化学检测（Immocare，Care Diagnostica公司）和生化检测（便潜血检测，Röhm Pharma公司），并比较了两者的结果。随后对所有患者进行了全结肠镜检查。免疫化学检测的灵敏度明显高于生化检测（分别为61.2%和29.4%），特异性略低于生化检测（分别为95%和98%）。Immocare检测的准确性也更高（82%，而便潜血检测为72%）。
我们的结果证实了便潜血检测在筛查和分级诊疗项目中的优势和适用性。更昂贵且操作更复杂的Immocare检测适用于有症状或有风险的患者。
