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地塞米松对黑腹果蝇针对寄生蜂的细胞免疫反应的抑制作用

Dexamethasone inhibition of the cellular immune response of Drosophila melanogaster against a parasitoid.

作者信息

Carton Yves, Frey Francoise, Stanley David W, Vass Emily, Nappi Anthony J

机构信息

Laboratoire Populations, Genetique et Evolution, CNRS, Gif-sur-Yvette, France.

出版信息

J Parasitol. 2002 Apr;88(2):405-7. doi: 10.1645/0022-3395(2002)088[0405:DIOTCI]2.0.CO;2.

DOI:10.1645/0022-3395(2002)088[0405:DIOTCI]2.0.CO;2
PMID:12054022
Abstract

Host larvae of Drosophila melanogaster injected with the eicosanoid biosynthesis inhibitor, dexamethasone, prior to parasitization by the wasp Leptopilina boulardi, exhibited significantly reduced rates of melanotic encapsulation in comparison with control and saline-injected larvae. The results of this investigation suggest that prostaglandins and other eicosanoids are involved as cell-signaling molecules in the hemocytic encapsulation reaction of D. melanogaster larvae.

摘要

在被黄蜂巴氏柔茧蜂寄生之前,用类花生酸生物合成抑制剂地塞米松注射黑腹果蝇的宿主幼虫,与对照幼虫和注射生理盐水的幼虫相比,其黑化包囊形成率显著降低。这项研究结果表明,前列腺素和其他类花生酸作为细胞信号分子参与了黑腹果蝇幼虫的血细胞包囊反应。

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