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本文引用的文献

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Effects of cannabinoids on adrenaline release from adrenal medullary cells.大麻素对肾上腺髓质细胞肾上腺素释放的影响。
Br J Pharmacol. 2001 Nov;134(6):1319-27. doi: 10.1038/sj.bjp.0704359.
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The endocannabinoid nervous system: unique opportunities for therapeutic intervention.内源性大麻素神经系统：治疗干预的独特机遇。
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3
Hemodynamic effects of cannabinoids: coronary and cerebral vasodilation mediated by cannabinoid CB(1) receptors.大麻素的血流动力学效应：由大麻素CB(1)受体介导的冠状动脉和脑血管舒张。
Eur J Pharmacol. 2001 Jul 6;423(2-3):203-10. doi: 10.1016/s0014-2999(01)01112-8.
4
Regional haemodynamic responses to the cannabinoid agonist, WIN 55212-2, in conscious, normotensive rats, and in hypertensive, transgenic rats.大麻素激动剂WIN 55212-2对清醒正常血压大鼠和高血压转基因大鼠的局部血流动力学反应。
Br J Pharmacol. 2001 Jun;133(3):445-53. doi: 10.1038/sj.bjp.0704100.
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Cannabinoids cause central sympathoexcitation and bradycardia in rabbits.大麻素可引起家兔中枢交感神经兴奋和心动过缓。
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Modulation of peristalsis by cannabinoid CB(1) ligands in the isolated guinea-pig ileum.大麻素CB(1)配体对离体豚鼠回肠蠕动的调节作用
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Effect of the cannabinoid receptor agonist WIN55212-2 on sympathetic cardiovascular regulation.大麻素受体激动剂WIN55212-2对交感神经心血管调节的影响。
Br J Pharmacol. 1999 Jan;126(2):457-66. doi: 10.1038/sj.bjp.0702337.
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Pharmacology of cannabinoid CB1 and CB2 receptors.大麻素CB1和CB2受体的药理学
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9
Binding of the non-classical cannabinoid CP 55,940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptors.非经典大麻素CP 55,940和二芳基吡唑AM251与啮齿动物脑大麻素受体的结合。
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10
Cannabinoid-induced hypotension and bradycardia in rats mediated by CB1-like cannabinoid receptors.大麻素在大鼠中通过类CB1大麻素受体介导引起低血压和心动过缓。
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CB(1)受体拮抗剂AM 251对WIN-55212-2或HU 210在清醒大鼠体内区域血流动力学效应的影响。

Influence of the CB(1) receptor antagonist, AM 251, on the regional haemodynamic effects of WIN-55212-2 or HU 210 in conscious rats.

作者信息

Gardiner S M, March J E, Kemp P A, Bennett T

机构信息

School of Biomedical Sciences, University of Nottingham Medical School, Queen's Medical Centre, Nottingham NG7 2UH, UK.

出版信息

Br J Pharmacol. 2002 Jun;136(4):581-7. doi: 10.1038/sj.bjp.0704750.

DOI:10.1038/sj.bjp.0704750
PMID:12055136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1573379/
Abstract

In conscious, freely-moving, male, Sprague-Dawley rats, the regional haemodynamic responses to the synthetic cannabinoids, WIN-55212-2 and HU 210, were compared. The possible involvement of cannabinoid, CB(1)-receptors, or beta(2)-adrenoceptors in the responses to WIN-55212-2 and HU 210 were investigated using the CB(1)-receptor antagonist, AM 251, or the beta(2)-adrenoceptor antagonist, ICI 118551, respectively. Both WIN-55212-2 (150 microg kg(-1)) and HU 210 (100 microg kg(-1)) had pressor, renal, and mesenteric vasoconstrictor and hindquarters vasodilator actions, although the effects of HU 210 were much more sustained than those of WIN-55212-2. Lower doses of the cannabinoids (WIN-55212-2, 50 microg kg(-1), HU 210, 10 microg kg(-1)) had less consistent actions. All the significant cardiovascular effects of WIN-55212-2 and HU 210 were antagonized by pretreatment with AM 251 (3 mg kg(-1)). Furthermore, pretreatment with the beta(2)-adrenoceptor antagonist, ICI 118551, inhibited the hindquarters vasodilator effects of WIN-55212-2 and of HU 210. On the basis of the present findings, and our earlier work, it is suggested that, in conscious rats, the pressor and vasoconstrictor effects of HU 210 and WIN-55212-2 involve cannabinoid-receptor-mediated increases in sympathetic activity. The accompanying hindquarters vasodilator actions of these agonists are cannabinoid receptor-mediated and appear to involve beta(2)-adrenoceptors.

摘要

在清醒、自由活动的雄性斯普拉格 - 道利大鼠中，比较了对合成大麻素WIN - 55212 - 2和HU 210的局部血流动力学反应。分别使用CB(1)受体拮抗剂AM 251或β(2)肾上腺素能受体拮抗剂ICI 118551，研究了大麻素CB(1)受体或β(2)肾上腺素能受体在对WIN - 55212 - 2和HU 210反应中的可能作用。WIN - 55212 - 2（150微克/千克）和HU 210（100微克/千克）均具有升压、肾和肠系膜血管收缩以及后肢血管舒张作用，尽管HU 210的作用比WIN - 55212 - 2更持久。较低剂量的大麻素（WIN - 55212 - 2，50微克/千克；HU 210，10微克/千克）作用不太一致。WIN - 55212 - 2和HU 210所有显著的心血管效应都被AM 251（3毫克/千克）预处理所拮抗。此外，β(2)肾上腺素能受体拮抗剂ICI 118551预处理抑制了WIN - 55212 - 2和HU 210的后肢血管舒张作用。基于目前的研究结果以及我们早期的工作，表明在清醒大鼠中，HU 210和WIN - 55212 - 2的升压和血管收缩作用涉及大麻素受体介导的交感神经活动增加。这些激动剂伴随的后肢血管舒张作用是大麻素受体介导的，并且似乎涉及β(2)肾上腺素能受体。