Honkanen Eero, Muroma-Karttunen R, Taponen R-M, Grönhagen-Riska C
Department of Medicine, Division of Nephrology, Helsinki University Cerntral Hospital, Kasarmikatu 11-13, FI-00130 Helsinki, Finland.
Scand J Urol Nephrol. 2002;36(2):137-44. doi: 10.1080/003655902753679445.
Home hemodialysis (HHD) has been used only in a minority of patients over past years although it may offer significant advantages over the other renal replacement therapies. This study describes the systems for and the initial results of starting a HHD program.
A program for HHD was instituted at a university hospital having more than 20 years of experience in training patients for self-care hemodialysis. A working group designed the patient and partner education program, installations, water quality assurance, logistics, and control systems.
Between May 1998 and May 2001, 37 patients with a mean age of 48.3 +/- 12.5 (24-71) years were trained for HHD (1.0 patient/month) the mean training time being 2.0 +/- 0.6 (1-3) months. Four patients had no helper at home. The dialysis schedules (timing, frequency, duration) were individualized at home 41% of the patients having more frequent and/or longer treatments (including long-slow night and daily short HHD). The weekly dialysis time increased from 13.9 +/- 1.5 (CI 13.4-14.4) initially to 15.5 +/- 3.7 (CI 14.2-16.7) h (p = 0.008) at the end of follow-up. Significantly (p < 0.05) increased serum creatinine concentration was observed during the follow-up suggesting for an increased muscle mass. Initially 32% and at the end of follow-up 60% of the patients required no antihypertensive drugs (p < 0.05). Seventeen of the 21 drop-outs were caused by renal transplantation and the most common causes necessitating hospital back-up were related to vascular access.
In conclusion the HHD program started in a unit having experience on and commitment for training self-care hemodialysis enabled individualization of the dialysis schedules resulting in the institution of long-slow (night) and alternate day as well as daily HHD therapies. It improved the control of hypertension renal transplantation being the single most common cause of drop-out.
家庭血液透析(HHD)在过去几年仅在少数患者中使用,尽管它可能比其他肾脏替代疗法具有显著优势。本研究描述了启动HHD项目的系统及初步结果。
在一所拥有20多年培训患者进行自我护理血液透析经验的大学医院开展了HHD项目。一个工作小组设计了患者及家属教育项目、设备安装、水质保证、后勤及控制系统。
1998年5月至2001年5月,37例平均年龄为48.3±12.5(24 - 71)岁的患者接受了HHD培训(每月1.0例患者),平均培训时间为2.0±0.6(1 - 3)个月。4例患者家中无帮手。透析方案(时间、频率、时长)在家庭中实现了个体化,41%的患者接受了更频繁和/或更长时间的治疗(包括长时间缓慢的夜间透析和每日短程HHD)。随访结束时,每周透析时间从最初的13.9±1.5(CI 13.4 - 14.4)小时增加到15.5±3.7(CI 14.2 - 16.7)小时(p = 0.008)。随访期间观察到血清肌酐浓度显著升高(p < 0.05)提示肌肉量增加。最初32%的患者在随访结束时60%的患者无需服用抗高血压药物(p < 0.05)。21例退出患者中有17例是由于肾移植,需要医院支持的最常见原因与血管通路有关。
总之,在一个有培训自我护理血液透析经验和投入的单位启动的HHD项目能够使透析方案个体化,从而实施长时间缓慢(夜间)、隔日以及每日HHD治疗。它改善了高血压的控制,肾移植是退出的唯一最常见原因。