Studies on absorption and elimination of drugs. Part VI: Fitting of a double exponential curve to the observed drug concentration after single extravascular administration.
作者信息
Danek A, Ksiezyk M, Mikolajek E
出版信息
Int J Clin Pharmacol Biopharm. 1975 Dec;12(4):437-45.
PMID:1205657
Abstract
A simple program was written in Algol 1204 for the Polish digital computer ODRA 1204. It permits the fitting of the Bateman equation C equals const [e-KEt -- e-KAt] or the equation C equals Be-KEt -- Ae-KAt to the observed plasma or serum concentration data after single extravascular administration of a drug. The results obtained with this M-31 program, compared with the calculations of the pharmacokinetic parameters for tetracycline HCl obtained with the Wagner's Nonline or Lag Time program, show a good conformity.
摘要
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