Kies M S, Bennett C L, Vokes E E
Thoracic/Head and Neck Medical Oncology, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 0800, Houston, Texas, 77030, USA.
Curr Treat Options Oncol. 2001 Feb;2(1):7-13. doi: 10.1007/s11864-001-0012-x.
The simultaneous administration of chemotherapy and radiation has produced a significant impact on the treatment of advanced squamous cell carcinomas of the head and neck. Although no single regimen has emerged as the "standard" approach, recent trials have consistently demonstrated the superiority of combined treatment programs over radiotherapy alone for local tumor control and overall survival. Moreover, multimodal treatment has emerged with important ancillary goals of organ preservation, improved cosmesis, and enhancement of quality of life. With improving survival in all stages of disease, much attention can be given to identifying effective measures to reduce the risk of metachronous primary cancers in this high-risk group.
化疗与放疗同时进行对头颈部晚期鳞状细胞癌的治疗产生了重大影响。尽管尚未出现单一的“标准”治疗方案，但近期试验一致表明，联合治疗方案在局部肿瘤控制和总生存率方面优于单纯放疗。此外，多模式治疗还带来了器官保留、改善美容效果和提高生活质量等重要的辅助目标。随着各疾病阶段生存率的提高，可将更多注意力放在确定有效措施以降低这一高危群体中异时性原发性癌症的风险上。
