Yop与紧密折叠的蛋白质结构域的融合及其对小肠结肠炎耶尔森菌Ⅲ型分泌的影响。
Yop fusions to tightly folded protein domains and their effects on Yersinia enterocolitica type III secretion.
作者信息
Lee Vincent T, Schneewind Olaf
机构信息
Department of Microbiology & Immunology, University of California Los Angeles School of Medicine, Los Angeles, California 90095, USA.
出版信息
J Bacteriol. 2002 Jul;184(13):3740-5. doi: 10.1128/JB.184.13.3740-3745.2002.
Abstract
Yersinia enterocolitica organisms secrete Yop proteins via the type III pathway. Translational fusion of yop genes to ubiquitin or dihydrofolate reductase results in hybrid proteins that cannot be secreted. The folding of hybrids prevents their own transport, but it does not hinder the type III secretion of other Yops.
摘要
小肠结肠炎耶尔森菌通过III型分泌途径分泌Yop蛋白。yop基因与泛素或二氢叶酸还原酶的翻译融合产生不能被分泌的杂合蛋白。杂合蛋白的折叠阻止了它们自身的转运，但并不妨碍其他Yop蛋白的III型分泌。
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