从蛇根木毛状根培养物中分离并鉴定一种新的吲哚生物碱：raumacline类的首个天然生物碱。

Isolation and structure elucidation of a new indole alkaloid from Rauvolfia serpentina hairy root culture: the first naturally occurring alkaloid of the raumacline group.

作者信息

Sheludko Yuri, Gerasimenko Irina, Kolshorn Heinz, Stöckigt Joachim

机构信息

Institute of Pharmacy, Johannes Gutenberg-University, Mainz, Germany.

出版信息

Planta Med. 2002 May;68(5):435-9. doi: 10.1055/s-2002-32074.

DOI:10.1055/s-2002-32074

PMID:12058321

Abstract

A new monoterpenoid indole alkaloid, 10-hydroxy- N(alpha)-demethyl-19,20-dehydroraumacline ( 1), was isolated as a mixture of E- and Z-isomers from hairy root culture of Rauvolfia serpentina Benth. ex Kurz (Apocynaceae) and the structure was determined by 1D and 2D NMR analyses. The new indole alkaloid represents the first naturally occurring alkaloid of the raumacline group and its putative biosynthetical pathway is discussed.

摘要

从萝芙木（Rauvolfia serpentina Benth. ex Kurz，夹竹桃科）的毛状根培养物中分离出一种新的单萜吲哚生物碱10-羟基-N(α)-去甲基-19,20-脱氢萝马cline（1），它是E-异构体和Z-异构体的混合物，其结构通过一维和二维核磁共振分析确定。这种新的吲哚生物碱是萝马cline类的首个天然存在的生物碱，并对其可能的生物合成途径进行了讨论。