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Characterization of a panel of monoclonal antibodies and mapping the epitopes of hepatitis C virus proteins.

作者信息

Masalova O V, Abdulmedzhidova A G, Atanadze S N, Lakina E I, Semiletov YuA, Burkov A N, Ulanova T I, Novikov V V, Pimenov V K, Filds G, Khudyakov YuE, Kushch A A

机构信息

Ivanovsky Research Institute of Virology, Russian Academy of Medical Sciences, ul. Gamaleya 16, Moscow, 123098 Russia.

出版信息

Dokl Biochem Biophys. 2002 Mar-Apr;383:125-9. doi: 10.1023/a:1015344003895.

DOI:10.1023/a:1015344003895
PMID:12058366
Abstract
摘要

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本文引用的文献

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Replication of hepatitis C virus.丙型肝炎病毒的复制
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Pathogenesis, diagnosis and management of hepatitis C.丙型肝炎的发病机制、诊断与管理
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HCV core immunodominant region analysis using mouse monoclonal antibodies and human sera: characterization of major epitopes useful for antigen detection.使用小鼠单克隆抗体和人血清进行丙型肝炎病毒核心免疫显性区域分析：用于抗原检测的主要表位的特征
J Med Virol. 1998 Dec;56(4):300-9. doi: 10.1002/(sici)1096-9071(199812)56:4<300::aid-jmv3>3.0.co;2-8.
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A comparative evaluation of the sensitivity of five anti-hepatitis C virus immunoblot assays.
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Human and murine antibody recognition is focused on the ATPase/helicase, but not the protease domain of the hepatitis C virus nonstructural 3 protein.人和小鼠抗体识别主要集中在丙型肝炎病毒非结构3蛋白的ATP酶/解旋酶结构域，而非蛋白酶结构域。
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Detection of hepatitis C virus core protein circulating within different virus particle populations.
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Analysis of hepatitis C virus core protein interaction domains.
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[Immunochemical properties and specificity of monoclonal antibodies against N- and C-terminal sites of the recombinant protein of the nucleocapsid of hepatitis C virus (HCcAg)].
Vopr Virusol. 1996 Jul-Aug;41(4):150-3.
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Linear B-cell epitopes of the NS3-NS4-NS5 proteins of the hepatitis C virus as modeled with synthetic peptides.用合成肽模拟的丙型肝炎病毒NS3-NS4-NS5蛋白的线性B细胞表位
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