Yang Young-Cheol, Lee Sang-Guei, Lee Hee-Kwon, Kim Moo-Key, Lee Sang-Hyun, Lee Hoi-Seon
Faculty of Biotechnology and Institute of Agricultural Science and Technology, College of Agriculture, Chonbuk National University, Chonju 561-756, South Korea.
J Agric Food Chem. 2002 Jun 19;50(13):3765-7. doi: 10.1021/jf011708f.
Mosquito larvicidal activity of Piper longum fruit-derived materials against the fourth-instar larvae of Aedes aegypti was examined. A crude methanol extract of P. longum fruits was found to be active against the larvae, and the hexane fraction of the methanol extract showed a strong larvicidal activity of 100% mortality. The biologically active component of P. longum fruits was characterized as pipernonaline by spectroscopic analyses. The LC(50) value of pipernonaline was 0.25 mg/L. The toxicity of pipernonaline is comparable to that of pirimiphos-methyl as a mosquito larvicide. In tests with available components derived from P. longum, no activity was observed with piperettine, piperine, or piperlongumine.
研究了荜茇果实提取物对埃及伊蚊四龄幼虫的杀蚊幼虫活性。发现荜茇果实的粗甲醇提取物对幼虫具有活性，甲醇提取物的己烷馏分表现出强烈的杀幼虫活性，死亡率达100%。通过光谱分析将荜茇果实的生物活性成分鉴定为胡椒壬碱。胡椒壬碱的LC(50)值为0.25 mg/L。作为一种杀蚊幼虫剂，胡椒壬碱的毒性与甲基嘧啶磷相当。在用荜茇的现有成分进行的测试中，未观察到胡椒亭碱、胡椒碱或荜茇明碱有活性。
