Nakatani Kazuhiko, Dohno Chikara, Saito Isao
Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, and CREST and PRESTO, Japan Science and Technology Corporation, Kyoto 606-8501, Japan.
J Am Chem Soc. 2002 Jun 19;124(24):6802-3. doi: 10.1021/ja025781d.
We have shown here that (1) substitution of an exocyclic amino group of dG is effective in modulating the chemical properties of dG toward one-electron oxidation and (2) decomposition of the guanine radical cation was effectively suppressed near dPhG. These results indicate that dPhG is a prototype of nucleosides functioning as an intrinsic antioxidant of duplex DNA toward one-electron oxidation.
（1）对dG的环外氨基进行取代可有效调节dG对单电子氧化的化学性质；（2）在dPhG附近，鸟嘌呤自由基阳离子的分解得到有效抑制。这些结果表明，dPhG是双链DNA对单电子氧化起内在抗氧化剂作用的核苷原型。
