Azad Rajeev K, Bernaola-Galván Pedro, Ramaswamy Ramakrishna, Rao J Subba
School of Environmental Sciences, Jawaharlal Nehru University, New Delhi 110 067, India.
Phys Rev E Stat Nonlin Soft Matter Phys. 2002 May;65(5 Pt 1):051909. doi: 10.1103/PhysRevE.65.051909. Epub 2002 May 8.
Genomic DNA is fragmented into segments using the Jensen-Shannon divergence. Use of this criterion results in the fragments being entropically homogeneous to within a predefined level of statistical significance. Application of this procedure is made to complete genomes of organisms from archaebacteria, eubacteria, and eukaryotes. The distribution of fragment lengths in bacterial and primitive eukaryotic DNAs shows two distinct regimes of power-law scaling. The characteristic length separating these two regimes appears to be an intrinsic property of the sequence rather than a finite-size artifact, and is independent of the significance level used in segmenting a given genome. Fragment length distributions obtained in the segmentation of the genomes of more highly evolved eukaryotes do not have such distinct regimes of power-law behavior.
利用詹森 - 香农散度将基因组DNA片段化。使用该标准会使片段在熵上达到预定统计显著性水平内的均匀性。此程序应用于古细菌、真细菌和真核生物的完整基因组。细菌和原始真核生物DNA中片段长度的分布呈现出两种不同的幂律标度模式。分隔这两种模式的特征长度似乎是序列的固有属性，而非有限尺寸假象，并且与用于分割给定基因组的显著性水平无关。在更高级进化的真核生物基因组分割中获得的片段长度分布不存在这种明显的幂律行为模式。
