Joffe R T, MacQueen G M, Marriott M, Robb J, Begin H, Young L T
Regional Mood Disorders Program, Department of Psychiatry and Behavioral Neuroscience, McMaster University, Hamilton, Ontario, Canada.
Acta Psychiatr Scand. 2002 Jun;105(6):427-30. doi: 10.1034/j.1600-0447.2002.02360.x.
To assess the effect of different antidepressants on induction of mania and cycle acceleration, commonly accepted unwanted effects of antidepressant treatment for acute bipolar depression. There is, however, the suggestion that certain classes of antidepressants may be less likely than others to cause these unwanted effects.
We conducted a prospective, open, naturalistic, life charting study to assess the occurrence of onset of mania and cycle acceleration attributable to two antidepressant classes: selective serotonin reuptake inhibitors (SSRIs) and bupropion.
No difference was found between the two drug classes for either antidepressant-induced mania or cycle acceleration. Antidepressant-induced mania was much more likely to occur in bipolar I rather than bipolar II patients. The overall occurrence of induction of mania and cycle acceleration was low across antidepressant classes.
These findings suggest that there is probably no difference in the risk of antidepressant-induced mania or cycle acceleration across commonly used classes of antidepressants for the treatment of bipolar depression.
评估不同抗抑郁药对躁狂发作诱导及循环加速的影响，这是抗抑郁药治疗急性双相抑郁时普遍公认的不良效应。然而，有观点认为某些种类的抗抑郁药比其他种类更不易引发这些不良效应。
我们开展了一项前瞻性、开放性、自然主义的生活图表研究，以评估两类抗抑郁药（选择性5-羟色胺再摄取抑制剂（SSRIs）和安非他酮）所致躁狂发作及循环加速的发生率。
在抗抑郁药诱发的躁狂或循环加速方面，两类药物之间未发现差异。抗抑郁药诱发的躁狂在双相I型患者中比双相II型患者更易发生。各类抗抑郁药诱发躁狂和循环加速的总体发生率较低。
这些发现表明，在治疗双相抑郁时，常用的各类抗抑郁药在诱发躁狂或循环加速的风险方面可能没有差异。
