Chilla R, Haubrich J
HNO. 1975 Jul;23(7):202-6.
In order to detect a possible influence of hormonal contraception on the development of vasomotor rhinitis, a five-months rhinoscopic survey was conducted on 460 women whose ages ranged from 18 to 40 years. 67 (32.7%) of the 205 women taking oral contraceptives, and 77 (30.2%) of a control group of 255 women were found to have vasomotor rhinitis. A questionaire was used in the survey, and included the following items: contraceptive preparation used, duration of use, and nasal distress associated with medication or prior pregnancies. In contrast to the findings of other authors, it was not possible to correlate the development of vasomotor rhinitis with the administration of oral contraceptives during the present study. Moreover, results were not altered by taking into account the composition of the different contraceptive drugs used. The statistical significance of the present study was established by the comparison of findings with a randomly selected control group of patients during the same period of time.
为了检测激素避孕对血管运动性鼻炎发展的可能影响,对460名年龄在18至40岁之间的女性进行了为期五个月的鼻镜检查。在205名服用口服避孕药的女性中,有67名(32.7%)被发现患有血管运动性鼻炎;在255名女性组成的对照组中,有77名(30.2%)被发现患有血管运动性鼻炎。该调查使用了一份问卷,其中包括以下项目:所使用的避孕制剂、使用时间以及与用药或既往妊娠相关的鼻部不适。与其他作者的研究结果相反,在本研究中无法将血管运动性鼻炎的发展与口服避孕药的使用联系起来。此外,考虑到所使用的不同避孕药的成分,结果并未改变。本研究的统计学意义是通过将研究结果与同期随机选择的对照组患者进行比较而确立的。