Robertson D, Michelakis A M
J Clin Endocrinol Metab. 1975 Dec;41(06):1166-8. doi: 10.1210/jcem-41-6-1166.
The response of plasma renin activity (PRA) and aldosterone to the intravenous administration of chlorpromazine was determined in schizophrenic patients while they were supine and on a normal sodium diet. In all subjects PRA and aldosterone increased during chlorpromazine administration with little or no change in blood pressure. The maximum PRA and aldosterone levels occurred 60 min after the higher dose of chlorpromazine. These data suggest that chlorpromazine affects the renin-angiotensin-aldosterone system and it may interfere with the evaluation of this system in patients receiving this drug.
在精神分裂症患者仰卧且正常钠饮食的情况下，测定了静脉注射氯丙嗪后血浆肾素活性（PRA）和醛固酮的反应。在所有受试者中，注射氯丙嗪期间PRA和醛固酮增加，而血压几乎没有变化。较高剂量氯丙嗪给药60分钟后出现PRA和醛固酮的最高水平。这些数据表明，氯丙嗪影响肾素-血管紧张素-醛固酮系统，并且可能干扰接受该药物治疗的患者中该系统的评估。
