Demeester-Mirkine N, Van Sande J, Corvilain J, Dumont J E
J Clin Endocrinol Metab. 1975 Dec;41(06):1169-71. doi: 10.1210/jcem-41-6-1169.
Cold thyroid nodules are generally due to impaired iodide uptake, while organification remains normal. In a case of a nodule appearing hot one hour after Tc99 m and cold 24 h after 131I-iodide, in vivo investigations showed that the trapping function was unimpaired and that the defect lay in organification. An early thyroid scan taken with 131I-iodide showed definite radioactivity in the nodule which was dischargeable by K perchlorate. This finding was confirmed by in vitro study of the tissue. Indirect evidence suggests that a defect was present in the H2O2 generating system rather than in peroxidase.
冷性甲状腺结节通常是由于碘摄取受损，而有机化过程仍正常。在一个病例中，一个结节在注射锝99m后1小时显热，而在注射131I-碘化物后24小时显冷，体内研究表明捕获功能未受损，缺陷在于有机化过程。用131I-碘化物进行的早期甲状腺扫描显示结节中有明确的放射性，高氯酸钾可使其排出。这一发现通过对组织的体外研究得到证实。间接证据表明，过氧化氢生成系统存在缺陷，而非过氧化物酶存在缺陷。
