使用反式-[en(2)Os(η2-H(2))(CF(3)SO(3))](CF(3)SO(3))以竞争模式研究抗肿瘤金属配合物与dGMP不同靶位点的结合量。
Study on the amount of binding of anti-tumor metal complexes to different target sites of dGMP using trans-[en(2)Os(eta2-H(2))(CF(3)SO(3))](CF(3)SO(3)) in a competitive mode.
作者信息
Yang Pin, Meng Xiang-Li, Yue Li-Jun, Wei Yi-Bin
机构信息
Institute of Molecular Science, Shanxi University, Taiyuan 030006, PR China.
出版信息
J Inorg Biochem. 2002 Apr 28;89(3-4):248-54. doi: 10.1016/s0162-0134(02)00380-x.
In order to investigate the binding sites and the amount of binding of a number of anti-tumor metal complexes (cisplatin, Cp(2)TiCl(2) and (CH(3))(2)SnCl(2)) to target molecule DNA mononucleotides in aqueous solution, a 1H NMR recognition probe, trans-en(2)Os(eta2-H(2))(CF(3)SO(3)), was used in a competitive mode. The minimum percentages of binding of anti-tumor metal complexes to different sites of dGMP were also determined.
为了研究多种抗肿瘤金属配合物（顺铂、二氯二茂钛和二氯二甲基锡）在水溶液中与靶分子DNA单核苷酸的结合位点及结合量，采用了一种1H NMR识别探针反式-乙二胺合锇（η2-H2）三氟甲磺酸酯，以竞争模式进行研究。还测定了抗肿瘤金属配合物与dGMP不同位点结合的最小百分比。
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