Ahmed Khalil, Gerber Delphine A, Cochet Claude
Cellular and Molecular Biochemistry Research Laboratory (151), Minneapolis Veterans Affairs Medical Center, Dept Laboratory Medicine and Pathology, MN 55417, USA.
Trends Cell Biol. 2002 May;12(5):226-30. doi: 10.1016/s0962-8924(02)02279-1.
Protein kinase CK2 (formerly known as casein kinase 2) is a serine/threonine protein kinase whose functions have been under investigation for over three decades, leading to the recognition that it interacts with several signaling pathways. Recent demonstrations of signal-mediated dynamic localization of CK2 and the identification of new signaling targets for it have converged to indicate an unexpected function for this protein kinase: cell survival. Here, we summarize our emerging knowledge about how CK2 might participate in the transduction of survival signals.
蛋白激酶CK2（以前称为酪蛋白激酶2）是一种丝氨酸/苏氨酸蛋白激酶，三十多年来其功能一直处于研究之中，这使得人们认识到它与多种信号通路相互作用。最近关于CK2信号介导的动态定位的证明以及其新信号靶点的鉴定，都表明这种蛋白激酶具有意想不到的功能：细胞存活。在此，我们总结了关于CK2如何参与存活信号转导的最新知识。
