Sorimachi Masaru, Yamagami Kazuhiko, Wakomori Minoru
Department of Physiology, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan.
Brain Res. 2002 May 10;935(1-2):129-33. doi: 10.1016/s0006-8993(02)02473-3.
ATP increased the cytosolic Ca(2+) concentration (Ca) in neurons of ventral tegmental area acutely dissociated from rat brain. The ATP response was dependent on external Ca(2+) and Na(+), and was blocked by voltage-dependent Ca(2+) channel blockers. The results suggest that the ATP-induced depolarization increases Ca(2+) influx via voltage-gated Ca(2+) channels resulting in the increase in Ca.
三磷酸腺苷（ATP）可使从大鼠脑急性分离出的腹侧被盖区神经元的胞质钙浓度（[Ca]i）升高。ATP反应依赖于细胞外钙和钠，并被电压依赖性钙通道阻滞剂阻断。结果表明，ATP诱导的去极化通过电压门控钙通道增加钙内流，导致[Ca]i升高。
