采用导数分光光度法在氢氯噻嗪存在的情况下测定厄贝沙坦。
Determination of irbesartan in the presence of hydrochlorothiazide by derivative spectrophotometry.
作者信息
Albero Isabel, Ródenas Vicente, García Soledad, Sánchez-Pedreño Concepción
机构信息
Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, 30071 Murcia, Spain.
出版信息
J Pharm Biomed Anal. 2002 Jun 20;29(1-2):299-305. doi: 10.1016/s0731-7085(02)00073-0.
A first-derivative spectrophotometric method for the determination of irbesartan (IRB) alone and in the presence of hydrochlorothiazide (HCT) is described. Measurements are made at the zero-crossing wavelength at 263.0 nm for IRB. The calibration graph was linear over the range 1.0-12.0 mg l(-1) of IRB, detection limit was 0.15 mg l(-1). HCT, in the presence of IRB was determined by direct spectrophotometric method at 317 nm. The calibration graph was linear over the range 2.0-50.0 mg l(-1) of HCT, detection limit was 0.25 mg l(-1). The proposed methods were successfully applied to the determinations of IRB and HCT in combined tablets.
描述了一种用于单独测定厄贝沙坦（IRB）以及在存在氢氯噻嗪（HCT）的情况下测定厄贝沙坦的一阶导数分光光度法。对IRB在263.0 nm的零交叉波长处进行测量。校准曲线在1.0 - 12.0 mg l⁻¹的IRB范围内呈线性，检测限为0.15 mg l⁻¹。在存在IRB的情况下，HCT通过在317 nm处的直接分光光度法测定。校准曲线在2.0 - 50.0 mg l⁻¹的HCT范围内呈线性，检测限为0.25 mg l⁻¹。所提出的方法成功应用于复方片剂中IRB和HCT的测定。
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