精神分裂症中与幻听相关的额颞叶功能连接减少。
Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations.
作者信息
Lawrie Stephen M, Buechel Christian, Whalley Heather C, Frith Christopher D, Friston Karl J, Johnstone Eve C
机构信息
University Department of Psychiatry, Royal Edinburgh Hospital, Morningside Park, Edinburgh, Scotland, UK.
出版信息
Biol Psychiatry. 2002 Jun 15;51(12):1008-11. doi: 10.1016/s0006-3223(02)01316-1.
BACKGROUND
We used functional magnetic resonance imaging (fMRI) to investigate the frontotemporal disconnection hypothesis of schizophrenia.
METHODS
Eight DSM-IV schizophrenia patients and 10 control subjects were studied with fMRI while they thought of the missing last word in 128 visually presented sentences. The fMRI data were analyzed comparing the effect of sentence completion (vs. rest) using a random effects analysis.
RESULTS
There were no significant group differences in regional brain responses. Correlation coefficients between left temporal cortex (x = -54, y = -42, z = 3) and left dorsolateral prefrontal cortex (x = -39, y = 12, z = 24) were significantly lower in the schizophrenic group and were negatively correlated with the severity of auditory hallucinations.
CONCLUSIONS
Previous demonstrations of hypofrontality in schizophrenia may reflect particular task requirements. Frontotemporal functional connectivity is reduced in schizophrenia and may be associated with auditory hallucinations.
背景
我们使用功能磁共振成像（fMRI）来研究精神分裂症的额颞叶断开连接假说。
方法
对8名符合《精神疾病诊断与统计手册》第四版（DSM-IV）标准的精神分裂症患者和10名对照受试者进行fMRI研究，让他们在脑海中想出128个视觉呈现句子中缺失的最后一个单词。使用随机效应分析比较句子完成（与休息相比）的效应，对fMRI数据进行分析。
结果
两组在脑区反应上没有显著差异。精神分裂症组左侧颞叶皮质（x = -54，y = -42，z = 3）与左侧背外侧前额叶皮质（x = -39，y = 12，z = 24）之间的相关系数显著更低，且与幻听严重程度呈负相关。
结论
先前关于精神分裂症前额叶功能低下的证明可能反映了特定的任务要求。精神分裂症患者的额颞叶功能连接性降低，可能与幻听有关。
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