Kanduc Darja, Mittelman Abraham, Serpico Rosario, Sinigaglia Eberta, Sinha Animesh A, Natale Costanzo, Santacroce Raffaella, Di Corcia M Grazia, Lucchese Alberta, Dini Luciana, Pani Paolo, Santacroce Salvatore, Simone Simone, Bucci Romano, Farber Emanuel
Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, USA.
Int J Oncol. 2002 Jul;21(1):165-70.
Cell death and the subsequent post-mortem changes, called necrosis, are integral parts of normal development and maturation cycle. Despite the importance of this process, the mechanisms underlying cell death are still poorly understood. In the recent literature, cell death is said to occur by two alternative, opposite modes: apoptosis, a programmed, managed form of cell death, and necrosis, an unordered and accidental form of cellular dying. The incorrect consequence is the overlapping of: a) the process whereby cells die, cell death; and b) the changes that the cells and tissues undergo after the cells die. Only the latter process can be referred to as necrosis and represents a
细胞死亡以及随后被称为坏死的死后变化，是正常发育和成熟周期不可或缺的组成部分。尽管这一过程很重要，但细胞死亡背后的机制仍知之甚少。在最近的文献中，细胞死亡被认为是通过两种交替且相反的方式发生的：凋亡，一种程序性、可控的细胞死亡形式；以及坏死，一种无序且意外的细胞死亡形式。错误的结果是：a) 细胞死亡的过程，即细胞死亡；与 b) 细胞死亡后细胞和组织所经历的变化之间存在重叠。只有后者这个过程才能被称为坏死，并且它代表了细胞生命中的一个“不可逆转”的过程。在这篇综述中，我们讨论了过去几十年在该领域开展的出色基础研究，以及在通过实验和机制上定义导致细胞死亡并表征细胞死亡的事件方面仍有待解决的问题。
