Lipoproteins and atherosclerosis in children: an early marriage?

AIM

Describe the relationship between serum lipoproteins and the development of atherosclerosis in young subjects aged 15-34 years, and discuss the implications for prevention of coronary heart disease.

DATA SYNTHESIS

Data from gross and microscopic evaluation of aorta and coronary arterial specimens as part of the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Study demonstrates that by the age of 15 years, all subjects have atherosclerosis. Lipoprotein risk factors for coronary heart disease are associated with the extent and prevalence of gross aortic and coronary atherosclerosis and with the development of microscopic coronary plaques that have qualities consistent with clinically significant lesions. Association of lipoprotein risk factors with intermediate type atherosclerotic lesions becomes evident in subjects in their late teens, whereas associations with raised lesions become evident in subjects greater than 25 years of age, consistent with a transitional role of intermediate lesion in the formation of advanced plaques.

CONCLUSIONS

Atherosclerosis begins in childhood and a significant number of young people have advanced coronary artery plaques. Early atherosclerosis is accelerated by lipoprotein risk factors. Thus, long-range prevention of atherosclerosis should begin in childhood and should include measures to control hyperlipidemia.