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[利用计算机软件对无名尸体进行间接分子遗传学鉴定]

[Use of computer software for indirect molecular genetic identification of unidentified bodies].

作者信息

Gabrileĭ Iu K, Kornienko I V, Shcherbakov V V, Ivanov P L

出版信息

Sud Med Ekspert. 2002 Mar-Apr;45(2):11-6.

Abstract

The authors discuss the development and use of computer software for realization of indirect DNA identification, based on identification of biological relation. Estimated algorithms of this method are based on regularities of parental signs inheritance by children and consist in comparative analysis of allele states of nuclear DNA typed locuses in unidentified bodies and probable parents of these dead subjects and subsequent estimation of the coefficients of the likelihood of hypotheses of their probable blood relationship. Available software maintain the database with identification characteristics of VNTR and STR locuses, HLA DQA1 locuses, and PM system (potential set of 23 locuses). The results of identification are presented as lists of exclusions and tables with estimated likelihood coefficients for the probability expert evaluation of relationship. The suggested computer-aided method of indirect identification is a new highly effective tool for personality identification by chromosome markers under conditions of mass information processing in examinations of unidentified corpses.

摘要

作者们讨论了基于生物关系鉴定实现间接DNA识别的计算机软件的开发与应用。该方法的估算算法基于子女遗传父母特征的规律,包括对身份不明尸体及其可能父母的核DNA分型位点的等位基因状态进行比较分析,随后估算他们可能存在血缘关系假设的似然系数。现有软件维护着包含VNTR和STR位点、HLA DQA1位点以及PM系统(23个位点的潜在集合)识别特征的数据库。识别结果以排除列表和带有似然系数估计值的表格形式呈现,用于关系概率的专家评估。所建议的间接识别计算机辅助方法是在身份不明尸体检验中进行大规模信息处理的条件下,通过染色体标记进行个体识别的一种新型高效工具。

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