Németh Anna Mária
Orv Hetil. 2002 May 12;143(19 Suppl):1099-108.
Somatostatin and its synthetic analogues have important physiological roles in human. These compounds antagonize the endocrine and exocrine secretion of pancreas, which provide theoretical ground for their use in patients with pancreatic diseases. For a quarter of a century many researchers have investigated the effect of somatostatin and octreotide in animal models of experimental pancreatitis and in patients with acute pancreatitis, and in those with complications of pancreatic operations, fistulas and pseudocysts. In most of these studies the use of synthetic octreotide with longer duration proved to be more efficient. In experimental and acute pancreatitis somatostatin and octreotide were less effective than expected, however, they proved to be helpful in preventing complications of pancreatic operations and in the therapy of fistulas and pseudocysts.
生长抑素及其合成类似物在人体中具有重要的生理作用。这些化合物可拮抗胰腺的内分泌和外分泌，这为它们用于胰腺疾病患者提供了理论依据。25年来，许多研究人员研究了生长抑素和奥曲肽在实验性胰腺炎动物模型、急性胰腺炎患者以及胰腺手术、瘘管和假性囊肿并发症患者中的作用。在大多数这些研究中，使用作用持续时间更长的合成奥曲肽被证明更有效。在实验性和急性胰腺炎中，生长抑素和奥曲肽的效果不如预期，但它们被证明有助于预防胰腺手术的并发症以及治疗瘘管和假性囊肿。
