可乐定可增强反苯环丙胺、苯乙肼及两种类似物在小鼠强迫游泳试验中的作用。
Clonidine potentiates the effects of tranylcypromine, phenelzine and two analogues in the forced swimming test in mice.
作者信息
Bourin Michel, Hascoët Martine, Colombel Marie Claude, Coutts Ronald T, Baker Glen B
机构信息
Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Edmonton, Alta.
出版信息
J Psychiatry Neurosci. 2002 May;27(3):178-85.
OBJECTIVE
To compare tranylcypromine (TCP) and phenelzine (PLZ), two well-established inhibitors of monoamine oxidase (MAO), and 2 of their analogues, 4-fluorotranylcypromine (FTCP) and N2-acetylphenelzine (AcPLZ) respectively, with regard to effects in the forced swimming test, a behavioural test used to screen for potential antidepressant drugs.
METHODS
Mice were dropped individually into glass cylinders containing water. The duration of their immobility was scored during the last 4 minutes of the test.
RESULTS
Except for TCP at high doses, none of the drugs demonstrated activity when administered alone. All 4 drugs were active when given in combination with clonidine, an effect thought to be the result of mixed action at 5-HT1A and 5-HT2 receptors and the noradrenergic system. 5-HT18 receptors do not seem to be implicated, as lithium did not potentiate the effect of any of the drugs. Quinine activation of AcPLZ suggests that this analogue acts on 5-HT3 receptors.
CONCLUSIONS
FTCP and AcPLZ demonstrated anti-immobility activity in the forced swimming test when used in association clonidine. These findings confirm previous neurochemical findings suggesting that these drugs have antidepressant properties.
目的
比较两种成熟的单胺氧化酶（MAO）抑制剂反苯环丙胺（TCP）和苯乙肼（PLZ），以及它们的两种类似物，即4-氟反苯环丙胺（FTCP）和N2-乙酰苯乙肼（AcPLZ）在强迫游泳试验中的效果，该试验是一种用于筛选潜在抗抑郁药物的行为测试。
方法
将小鼠单独放入盛有水的玻璃圆筒中。在试验的最后4分钟记录其不动时间。
结果
除高剂量的TCP外，单独给药时这些药物均未表现出活性。与可乐定联合给药时，所有4种药物均有活性，这种效应被认为是5-HT1A和5-HT2受体以及去甲肾上腺素能系统混合作用的结果。5-HT18受体似乎未参与其中，因为锂不能增强任何一种药物的作用。奎宁对AcPLZ的激活表明该类似物作用于5-HT3受体。
结论
FTCP和AcPLZ与可乐定联合使用时，在强迫游泳试验中表现出抗不动活性。这些发现证实了先前的神经化学研究结果，表明这些药物具有抗抑郁特性。
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