Bueno José M, Chicharro Jesús, Fiandor José M, Gómez de las Heras Federico, Huss Sophie
GlaxoSmithkline, Research Department, Parque Tecnológico de Madrid, Severo Ochoa, 2.28760 Tres Cantos, Madrid, Spain.
Bioorg Med Chem Lett. 2002 Jul 8;12(13):1697-700. doi: 10.1016/s0960-894x(02)00293-7.
A series of Sordarin derivatives bearing alkyl substituted tetrahydrofuran rings fused to C3'-C4' bond of the sugar moiety have been prepared and their antifungal properties evaluated. Most of them show remarkable antifungal activity against Candida spp and Cryptococcus neoformans.
已制备了一系列糖部分的C3'-C4'键与烷基取代的四氢呋喃环稠合的索拉菌素衍生物，并评估了它们的抗真菌特性。其中大多数对念珠菌属和新型隐球菌显示出显著的抗真菌活性。
