Ma Jianmin, Zhou Tong, Gu Wanjun, Sun Xiao, Lu Zuhong
Chien-Shiung Wu Laboratory, Southeast University, 210096 Jiangsu Province, Nanjing, People's Republic of China.
Biosystems. 2002 Mar-May;65(2-3):199-207. doi: 10.1016/s0303-2647(02)00016-3.
The relative synonymous codon use frequency of 135 MHC genes from four mammal species (Homo sapiens, Pan troglodyte, Macaca mulanta and Rattus norvegicus) is analyzed using a hierarchical cluster method. The result suggests that gene function is the dominant factor that determines codon usage bias, while species is a minor factor that determines further difference in codon usage bias for genes with similar functions. The conclusion may be useful in gene classification and gene function prediction.
采用层次聚类方法分析了来自四种哺乳动物物种（智人、黑猩猩、猕猴和褐家鼠）的135个MHC基因的相对同义密码子使用频率。结果表明，基因功能是决定密码子使用偏好的主导因素，而物种是决定具有相似功能的基因在密码子使用偏好上进一步差异的次要因素。该结论可能对基因分类和基因功能预测有用。
