齐多夫定的压力加速了1型人类免疫缺陷病毒逆转录酶中赋予拉米夫定耐药性的M184V突变的逆转。
Pressure of zidovudine accelerates the reversion of lamivudine resistance-conferring M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1.
作者信息
Diallo Karidia, Oliveira Maureen, Moisi Daniela, Brenner Bluma, Wainberg Mark A, Götte Matthias
机构信息
McGill University AIDS Centre, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec, Canada.
出版信息
Antimicrob Agents Chemother. 2002 Jul;46(7):2254-6. doi: 10.1128/AAC.46.7.2254-2256.2002.
Abstract
We cultured lamivudine-resistant human immunodeficiency virus type 1 (HIV-1) variants over an extended period of time in the presence of zidovudine and observed a premature reversion of the resistance-conferring M184V mutation. These data suggest that the presence of ZDV amplifies differences in replication capacity between wild-type HIV-1 and the mutant variant.
摘要
我们在齐多夫定存在的情况下，长时间培养对拉米夫定耐药的1型人类免疫缺陷病毒（HIV-1）变体，观察到赋予耐药性的M184V突变出现过早回复。这些数据表明，齐多夫定的存在放大了野生型HIV-1与突变体变体之间复制能力的差异。
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