• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

齐多夫定的压力加速了1型人类免疫缺陷病毒逆转录酶中赋予拉米夫定耐药性的M184V突变的逆转。

Pressure of zidovudine accelerates the reversion of lamivudine resistance-conferring M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1.

作者信息

Diallo Karidia, Oliveira Maureen, Moisi Daniela, Brenner Bluma, Wainberg Mark A, Götte Matthias

机构信息

McGill University AIDS Centre, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec, Canada.

出版信息

Antimicrob Agents Chemother. 2002 Jul;46(7):2254-6. doi: 10.1128/AAC.46.7.2254-2256.2002.

DOI:10.1128/AAC.46.7.2254-2256.2002
PMID:12069983
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC127311/
Abstract

We cultured lamivudine-resistant human immunodeficiency virus type 1 (HIV-1) variants over an extended period of time in the presence of zidovudine and observed a premature reversion of the resistance-conferring M184V mutation. These data suggest that the presence of ZDV amplifies differences in replication capacity between wild-type HIV-1 and the mutant variant.

摘要

我们在齐多夫定存在的情况下，长时间培养对拉米夫定耐药的1型人类免疫缺陷病毒（HIV-1）变体，观察到赋予耐药性的M184V突变出现过早回复。这些数据表明，齐多夫定的存在放大了野生型HIV-1与突变体变体之间复制能力的差异。

相似文献

1
Pressure of zidovudine accelerates the reversion of lamivudine resistance-conferring M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1.齐多夫定的压力加速了1型人类免疫缺陷病毒逆转录酶中赋予拉米夫定耐药性的M184V突变的逆转。
Antimicrob Agents Chemother. 2002 Jul;46(7):2254-6. doi: 10.1128/AAC.46.7.2254-2256.2002.
2
The M184V mutation in HIV-1 reverse transcriptase (RT) conferring lamivudine resistance does not result in broad cross-resistance to nucleoside analogue RT inhibitors.导致拉米夫定耐药的HIV-1逆转录酶（RT）中的M184V突变不会导致对核苷类似物逆转录酶抑制剂产生广泛的交叉耐药性。
AIDS. 1998 May 7;12(7):705-12. doi: 10.1097/00002030-199807000-00006.
3
Increased drug susceptibility of HIV-1 reverse transcriptase mutants containing M184V and zidovudine-associated mutations: analysis of enzyme processivity, chain-terminator removal and viral replication.含有M184V和齐多夫定相关突变的HIV-1逆转录酶突变体的药物敏感性增加：酶持续合成能力、链终止剂去除及病毒复制分析
Antivir Ther. 2001 Jun;6(2):115-26.
4
Loss of lamivudine resistance in a zidovudine and lamivudine dual-resistant HIV-1 isolate after discontinuation of in vitro lamivudine drug pressure.在体外停用拉米夫定药物压力后，齐多夫定和拉米夫定双重耐药的HIV-1分离株中拉米夫定耐药性丧失。
Antivir Ther. 1998;3(4):203-7.
5
Interaction of reverse transcriptase (RT) mutations conferring resistance to lamivudine and etravirine: effects on fitness and RT activity of human immunodeficiency virus type 1.逆转录酶（RT）突变体与拉米夫定和依曲韦林耐药性的相互作用：对人类免疫缺陷病毒 1 型的适应性和 RT 活性的影响。
J Virol. 2011 Nov;85(21):11309-14. doi: 10.1128/JVI.05578-11. Epub 2011 Aug 17.
6
Prevalence of primary resistance to zidovudine and lamivudine in drug-naive human immunodeficiency virus type-1 infected patients: high proportion of reverse transcriptase codon 215 mutant in circulating lymphocytes and free virus.初治的人类免疫缺陷病毒1型感染患者中对齐多夫定和拉米夫定原发性耐药的患病率：循环淋巴细胞和游离病毒中逆转录酶密码子215突变比例高。
J Med Virol. 2000 Jul;61(3):352-9.
7
Long-term foscarnet therapy remodels thymidine analogue mutations and alters resistance to zidovudine and lamivudine in HIV-1.长期膦甲酸钠治疗可重塑HIV-1中的胸苷类似物突变，并改变对齐多夫定和拉米夫定的耐药性。
Antivir Ther. 2007;12(3):335-43.
8
Mechanisms by which the G333D mutation in human immunodeficiency virus type 1 Reverse transcriptase facilitates dual resistance to zidovudine and lamivudine.人类免疫缺陷病毒1型逆转录酶中的G333D突变促进对齐多夫定和拉米夫定双重耐药的机制。
Antimicrob Agents Chemother. 2008 Jan;52(1):157-63. doi: 10.1128/AAC.00904-07. Epub 2007 Oct 29.
9
Impaired rescue of chain-terminated DNA synthesis associated with the L74V mutation in human immunodeficiency virus type 1 reverse transcriptase.与人类免疫缺陷病毒1型逆转录酶L74V突变相关的链终止DNA合成修复受损。
Antimicrob Agents Chemother. 2005 Jul;49(7):2657-64. doi: 10.1128/AAC.49.7.2657-2664.2005.
10
Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.在第41、184和215密码子处含有突变的齐多夫定或拉米夫定耐药的1型人类免疫缺陷病毒逆转录酶的晶体结构
J Virol. 2002 Oct;76(19):10015-9. doi: 10.1128/jvi.76.19.10015-10019.2002.

引用本文的文献

1
Reversing resistance: different routes and common themes across pathogens.逆转耐药性：病原体的不同途径与共同主题
Proc Biol Sci. 2017 Sep 27;284(1863). doi: 10.1098/rspb.2017.1619.
2
Persistence versus reversion of 3TC resistance in HIV-1 determine the rate of emergence of NVP resistance.3TC 耐药的持续存在与逆转决定了 NVP 耐药的出现率。
Viruses. 2012 Aug;4(8):1212-34. doi: 10.3390/v4081212. Epub 2012 Aug 7.
3
Molecular impact of the M184V mutation in human immunodeficiency virus type 1 reverse transcriptase.人类免疫缺陷病毒1型逆转录酶中M184V突变的分子影响
Antimicrob Agents Chemother. 2003 Nov;47(11):3377-83. doi: 10.1128/AAC.47.11.3377-3383.2003.
4
Reversion of the M184V mutation in simian immunodeficiency virus reverse transcriptase is selected by tenofovir, even in the presence of lamivudine.即使在拉米夫定存在的情况下，替诺福韦也能选择出猿猴免疫缺陷病毒逆转录酶中M184V突变的回复突变。
J Virol. 2003 Jan;77(2):1120-30. doi: 10.1128/jvi.77.2.1120-1130.2003.

本文引用的文献

1
Resistance to nucleoside analog reverse transcriptase inhibitors mediated by human immunodeficiency virus type 1 p6 protein.由1型人类免疫缺陷病毒p6蛋白介导的对核苷类似物逆转录酶抑制剂的耐药性
J Virol. 2001 Oct;75(20):9644-53. doi: 10.1128/JVI.75.20.9644-9653.2001.
2
Biochemical mechanisms involved in overcoming HIV resistance to nucleoside inhibitors of reverse transcriptase.克服HIV对逆转录酶核苷类抑制剂耐药性所涉及的生化机制。
Drug Resist Updat. 2000 Feb;3(1):30-38. doi: 10.1054/drup.2000.0126.
3
Phenotypic hypersusceptibility to non-nucleoside reverse transcriptase inhibitors in treatment-experienced HIV-infected patients: impact on virological response to efavirenz-based therapy.经治的HIV感染患者对非核苷类逆转录酶抑制剂的表型超敏感性：对基于依非韦伦治疗的病毒学应答的影响
AIDS. 2001 Jun 15;15(9):1125-32. doi: 10.1097/00002030-200106150-00007.
4
The M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1 impairs rescue of chain-terminated DNA synthesis.1型人类免疫缺陷病毒逆转录酶中的M184V突变会损害链终止DNA合成的挽救。
J Virol. 2000 Apr;74(8):3579-85. doi: 10.1128/jvi.74.8.3579-3585.2000.
5
In vitro selection and characterization of HIV-1 with reduced susceptibility to PMPA.对替诺福韦酯敏感性降低的HIV-1的体外筛选与特性分析
Antivir Ther. 1999;4(2):87-94. doi: 10.1177/135965359900400205.
6
Zidovudine resensitization and dual HIV-1 resistance to zidovudine and lamivudine in the delta lamivudine roll-over study.在拉米夫定转换研究中齐多夫定再致敏及HIV-1对齐多夫定和拉米夫定的双重耐药性
Antivir Ther. 1999;4(2):69-77.
7
Loss of lamivudine resistance in a zidovudine and lamivudine dual-resistant HIV-1 isolate after discontinuation of in vitro lamivudine drug pressure.在体外停用拉米夫定药物压力后，齐多夫定和拉米夫定双重耐药的HIV-1分离株中拉米夫定耐药性丧失。
Antivir Ther. 1998;3(4):203-7.
8
A new point mutation (P157S) in the reverse transcriptase of human immunodeficiency virus type 1 confers low-level resistance to (-)-beta-2',3'-dideoxy-3'-thiacytidine.人类免疫缺陷病毒1型逆转录酶中的一种新的点突变（P157S）赋予了对（-）-β-2'，3'-二脱氧-3'-硫代胞苷的低水平抗性。
Antimicrob Agents Chemother. 1999 Aug;43(8):2077-80. doi: 10.1128/AAC.43.8.2077.
9
A novel polymorphism at codon 333 of human immunodeficiency virus type 1 reverse transcriptase can facilitate dual resistance to zidovudine and L-2',3'-dideoxy-3'-thiacytidine.人类免疫缺陷病毒1型逆转录酶第333位密码子处的一种新型多态性可促成对齐多夫定和L-2'，3'-二脱氧-3'-硫代胞苷的双重耐药性。
J Virol. 1998 Jun;72(6):5093-8. doi: 10.1128/JVI.72.6.5093-5098.1998.
10
Zidovudine resistance is suppressed by mutations conferring resistance of human immunodeficiency virus type 1 to foscarnet.齐多夫定耐药性可被赋予人类免疫缺陷病毒1型对膦甲酸钠耐药性的突变所抑制。
J Virol. 1996 Oct;70(10):7171-81. doi: 10.1128/JVI.70.10.7171-7181.1996.