Räsänen Jukka, Gavriely Noam
Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, USA.
J Appl Physiol (1985). 2002 Jul;93(1):51-7. doi: 10.1152/japplphysiol.01238.2001.
To evaluate the utility of monitoring the sound-filtering characteristics of the respiratory system in the assessment of acute lung injury (ALI), we injected a multifrequency broadband sound signal into the airway of five anesthetized, intubated pigs, while recording transmitted sound over the trachea and on the chest wall. Oleic acid injections effected a severe lung injury predominantly in the dependent lung regions, increasing venous admixture from 6 +/- 1 to 54 +/- 8% (P < 0.05) and reducing dynamic respiratory system compliance from 19 +/- 0 to 12 +/- 2 ml/cmH(2)O (P < 0.05). A two- to fivefold increase in sound transfer function amplitude was seen in the dependent (P < 0.05) and lateral (P < 0.05) lung regions; no change occurred in the nondependent areas. High within-subject correlations were found between the changes in dependent lung sound transmission and venous admixture (r = 0.82 +/- 0.07; range 0.74-0.90) and dynamic compliance (r = -0.87 +/- 0.05; -0.80 to -0.93). Our results indicate that the acoustic changes associated with oleic acid-induced lung injury allow monitoring of its severity and distribution.
为评估监测呼吸系统声音过滤特性在急性肺损伤（ALI）评估中的作用，我们向五只麻醉、插管的猪的气道内注入多频宽带声音信号，同时记录气管和胸壁上的传输声音。油酸注射主要在肺下垂部位造成严重肺损伤，使静脉混合血从6±1%增加到54±8%（P<0.05），并使动态呼吸系统顺应性从19±0 ml/cmH₂O降低到12±2 ml/cmH₂O（P<0.05）。在肺下垂部位（P<0.05）和外侧部位（P<0.05），声音传递函数幅度增加了两到五倍；非下垂部位无变化。在肺下垂部位声音传输变化与静脉混合血（r = 0.82±0.07；范围0.74 - 0.90）和动态顺应性（r = -0.87±0.05；-0.80至-0.93）之间发现了较高的受试者内相关性。我们的结果表明，与油酸诱导的肺损伤相关的声学变化能够监测其严重程度和分布情况。
