Scott Eleanor M, Greenwood John P, Stoker John B, Mary David A S G, Gilbey Stephen G
Department of Endocrinology, St. James's University Hospital, Leeds, UK.
Clin Endocrinol (Oxf). 2002 Jun;56(6):759-63. doi: 10.1046/j.1365-2265.2002.01546.x.
Hypopituitary patients with untreated GH deficiency have increased cardiovascular mortality. Sustained vasoconstriction is an important factor in the development of hypertension and insulin resistance. This study was designed to see whether peripheral vascular resistance was increased in subjects with GH deficiency and to examine the mechanisms involved.
Nine patients with GH deficiency and nine matched control subjects were studied. Calf vascular resistance was measured by venous occlusion plethysmography and sympathetic vasoconstrictor nerve activity by peroneal microneurography.
Subjects with GH deficiency had a significantly lower blood flow (by 31%) and higher vascular resistance (by 48%) than the control group. In addition, they had a significantly higher sympathetic vasoconstrictor activity (by 67%) and this correlated with the vascular resistance (r = 0.45; P < 0.04).
Patients with GH deficiency have an increased peripheral vascular resistance that is contributed to by an increase in central sympathetic vasoconstrictor discharge to the peripheral vasculature. This could be important in the development of cardiovascular disease in this condition.
未治疗的生长激素缺乏性垂体功能减退患者心血管死亡率增加。持续性血管收缩是高血压和胰岛素抵抗发生发展的重要因素。本研究旨在观察生长激素缺乏患者的外周血管阻力是否增加，并探讨其相关机制。
对9例生长激素缺乏患者和9例匹配的对照者进行研究。采用静脉阻塞体积描记法测量小腿血管阻力，通过腓骨微神经ography测量交感缩血管神经活动。
生长激素缺乏患者的血流量显著低于对照组（降低31%），血管阻力显著高于对照组（升高48%）。此外，他们的交感缩血管活性显著更高（升高67%），且与血管阻力相关（r = 0.45；P < 0.04）。
生长激素缺乏患者外周血管阻力增加，这是由于中枢交感缩血管神经向外周血管系统的放电增加所致。这在该疾病心血管疾病的发生发展中可能具有重要意义。
