树突状细胞上的CD83：不仅仅是成熟的标志物。

CD83 on dendritic cells: more than just a marker for maturation.

作者信息

Lechmann Matthias, Berchtold Susanne, Hauber Joachim, Steinkasserer Alexander

机构信息

Dept of Dermatology, University of Erlangen-Nürnberg, Hartmannstrasse 14, D-91052, Erlangen, Germany.

出版信息

Trends Immunol. 2002 Jun;23(6):273-5. doi: 10.1016/s1471-4906(02)02214-7.

DOI:10.1016/s1471-4906(02)02214-7

PMID:12072358

Abstract

CD83 has been known for a long time to be one of the best markers for mature dendritic cells (DCs). Studies with herpes simplex virus type 1 (HSV-1)-infected DCs, whereby the viral infection leads to the degradation of CD83, as well as investigations inhibiting CD83 mRNA transport, have provided evidence that CD83 might also be important for DC biology. Recently, we have shown that the soluble extracellular CD83 domain inhibits DC-mediated T-cell proliferation, representing the first report describing a functional role for CD83.

摘要

长期以来，CD83一直被认为是成熟树突状细胞（DC）的最佳标志物之一。对1型单纯疱疹病毒（HSV-1）感染的DC进行的研究表明，病毒感染会导致CD83降解，以及对抑制CD83 mRNA转运的研究，都提供了证据表明CD83可能对DC生物学也很重要。最近，我们发现可溶性细胞外CD83结构域可抑制DC介导的T细胞增殖，这是描述CD83功能作用的首篇报道。