Volm M
Langenbecks Arch Chir. 1975 Nov;339:121-6. doi: 10.1007/BF01257499.
On the basis of animal experiments it is shown that the results of tumor chemotherapy can be predicted with the aid of in-vitro test systems. In investigations carried out on human tumors, the correlations obtained between in-vitro test results and response to therapy are promising. However, definitive proof of a correlation can only be provided by planned, statistically supported clinical studies. Two types of information can already be obtained from the in-vitro tests: data concerning the rate of proliferation of the tumor, on which the activity of cytostatic agents depends, and data on certain types of resistance to cytostatics.
基于动物实验表明，借助体外测试系统可以预测肿瘤化疗的结果。在对人类肿瘤进行的研究中，体外测试结果与治疗反应之间获得的相关性很有前景。然而，相关性的确切证据只能由有计划的、有统计学支持的临床研究来提供。从体外测试中已经可以获得两类信息：关于肿瘤增殖速率的数据（细胞抑制剂的活性取决于此）以及关于对细胞抑制剂某些类型耐药性的数据。
